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W., Jal, E., Bonetti, S., Gray, A. X., Graves, C. E., Kukreja, R., Chen, Z., Higley, D. Transient expression of Gal 3 in mouse N2a cells significantly enhanced meningococcal invasion when compared with non transfected cells. Moreover, infection of CD46 expressing transgenic mice with meningococcal strain MC58 significantly increased the expression of Gal 3 and 37 LRP in the brain.This work also attempts to study whether the 37 LRP/67 LR meningococcal ligands (rPorA, loop 4 of PorA and rPilQ) have any influence on the surface level of 67 LR and Gal 3. As indicated by flow cytometry analysis, recruitments of 67 LR and Gal 3 to the surface of HBMECs were increased in cells incubated with rPilQ, Loop 4 of PorA and more prominently rPorA.

Moving AverageThe average price of a security over a certain time period, calculated continuously. For instance, one may calculate a moving average by adding prices from the most recent trading days (for example, the last 10 days) and dividing by the number of trading days considered (in this case, 10). A moving average may or may not be weighted.

According to her husband, Reza Khandan, She has stated that she has withdrawn her appeals request. Now she is no longer in solitary confinement but in a section where the prisoners can not have any visitors. During all these 9 and half months she could only visit her daughter of 12 and her son of 3 years only 3 times ,for 40 minutes in total.

And prayers to his wonderful mother, wife, children, and the entire Vergos family. I’ve known Nick Vergos for more than 25 years and knew his commitment to his family and their iconic Rendezvous. He will be missed. Which would Advanced Micro Devices CEO Hector Ruiz prefer a new Hill Country campus located minutes away from his Barton Creek Country Club home, or a tasteful monument erected in his honor? If environmental doyenne Shudde Fath has her way, Ruiz would choose the latter, because it would serve as his reward for retreating from the Barton Springs watershed site where AMD plans to build its new corporate offices. Fath addressed the City Council last week on behalf of the Save Barton Creek Association, but she chose to put a positive spin on the group’s recently passed resolution, which actually calls for a monument that admonishes Ruiz for disregarding the wishes of the community in choosing to build an 850,000 square foot complex in the sensitive watershed. “Since I truly prefer the positive to the negative,” Shudde told the council, I am proposing honors and accolades for Hector Ruiz, if he will recognize our community values and give up the watershed site.” What say you, Hector? Amy Smith.

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Given botched executions, including one in Arizona where the condemned man took nearly two hours to die, more states are looking at viable back ups to lethal injection. Tennessee has reinstated its electric chair, and Arkansas lawmakers have filed a bill to allow firing squads. Oklahoma lawmakers are discussing a plan to use nitrogen gas as the lethal element..

The aim of this study was to provide an overview of studies in which the impact of the 2008 economic crisis on child health was reported. Structured searches of PubMed, and ISI Web of Knowledge, were conducted. Quantitative and qualitative studies reporting health outcomes on children, published since 2007 and related to the 2008 economic crisis were included.

Brooks award in 2004. She was a board member with the House of Sophrosyne and was honored in the early 1990s with the CAW Break the Silence award and the local Woman of the Year award.Heavy lifters Derek Mercer, left, John Snider and Marc Bellavance of Bellevance Nursery carry large rolls of sod as Shawn Quinlan, right, of Homescapes swings a pick at the Shirley and Ray Gould’s Community Garden on Cantelon Drive, Wednesday June 18, 2014. The project, spearheaded by The Unemployed Help Centre, will be more than just a garden for food bank clients.

Manchester Crown CourtBoy, 17, allegedly raped then attempted to murder his ex girlfriend to prove to his current partner that he loved her, jury toldThe boy, 17, is on trial accused of the attempted murder and rape of the girl, the mother of his child who was 16 at the timeManchester Crown CourtRapist who attacked sex worker after she turned him away when he offered her 5 was caught after he gave her a ‘love bite”It changed me as a person, I don’t feel the same inside,’ she said as her attacker sobbed in the dockAncoatsManchester City fan threw traffic cone during ‘disgraceful’ mass brawl before derbyCity supporter Callum Wright, 23, appeared at Manchester Crown Court after being picked out on CCTV footageCourts’Everyone was just screaming and fighting’: Joe O’Brien murder trial told of chaos outside Royal Oak pub in FailsworthMr Jallow, 21, Daniel Kamara, 22, and Darius Evans, 18, all deny murdering 24 year old Joe O’Brien during a fracas on Oldham Road in Failsworth, near the Royal Oak pubOpenshawHis cannabis farm was broken into. Investigates some of the most shocking cases our reporters have covered in 2019. The details of their crimes are shocking, but knowing them could help protect a child from another predator.SalfordMan shot following claims the victim had been to shooter’s mum’s house in a balaclava and threatened the familyRobert White later claimed he couldn’t remember where he had been on the night of the shooting, telling police he was ‘probably at McDonald’s’ he and three other men have been jailedWiganThe frightening speeds two drivers reached before killing an innocent mum of five in a horror collision now they’ve been jailedLewis Fisher, 21, and Joseph Pownall, 27, have been jailed for 11 and 12 years respectivelyWiganGuilty: The laughing Mercedes driver who killed mum of five while ‘having a joke’ during high speed chaseLewis Fisher, 21, faces a lengthy jail term after being found guilty of causing the death of Joanne Bailey Collinge by dangerous drivingMiles PlattingDriver with heroin and a knife in car only stopped for police after crashing into a speed limit signJack Griffin, 24, had 13 wraps of heroin and a lock knife in his Vauxhall Meriva when stopped by the policeGig venues across the city joined together for the annual festival this weekendCheshireHe burned his jumper, threw the bloodied crowbar in a pond and tried to cover his tracks with phoney texts.

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Aerial view of the Vehicle Assembly Building (VAB) at NASA’s Kennedy Space Center (KSC) on Oct. 8, 2016 by damage assessment and recovery team surveying the damage at KSC the day after Hurricane Matthew passed by Cape Canaveral on Oct. 7, 2016 packing sustained winds of 90 mph with gusts to 107 mph.

A vision statement spells out the future direction of an organization and where it sees itself in the long term. Great business organizations in history have always been built by leaders who had a great vision. There are several excellent examples of vision statements from organizations that have achieved extraordinary success and global leadership in fields they had envisioned for themselves..

“We left ‘Brokeland’ for cheap living and cheaper lovin,” band co founder Ted Nesseth said in an email interview. “(San Francisco and Oakland) were good to us, and we have strong ties there, so it was hard to leave. But we decided to start up incognito here and try to earn our way into it, and it’s gone well.”.

“One of the things I like to propagate in a session is I like it to be fun. Because I really think that the state of mind that you are in while you are doing your work ends up translating to the final product. And when we did Snakes and Arrows, it was basically three months where we were just laughing our faces off.

Trois subalternes ou relations de Klor ont aussi plaid coupables, jeudi, diffrentes accusations, soit Christopher Gingras, 22 ans, Bashar Elsaad, 22 ans, et Stphanie Chicoine, 23 ans. Les deux derniers sont en libert sous cautionnement. M. The cavities, while full of water can support the surface materials because water is not compressible. When a near surface cavity empties of water, a surface collapse can occur above the cavity due to decreased back pressure from lack of water. Understanding Urban Development Is Dependent On Karst Landscapes Central Florida s “urban development” should be managed based on karst rock topography attributes.

4 Advantages of Working with a Boutique Marketing Agency By Edmund BrunettiMarketing has changed dramatically in the last several decades. In the past, traditional marketing included print ads, posters, billboards, newsletters . Brand needs as well as the goal you wish to accomplish.

R., Anderson, S. R., Coles, M. C., Farrow, S. Groom. Groom. GROOM! Find a good groomer and get them groomed often. Catholic priest says he denied Joe Biden Holy Communion at Mass in South Carolina because of abortion viewsFormer Vice President Joe Biden was denied Holy Communion at a Catholic church in South Carolina on Sunday morning because of his views on abortion, a priest said in a statement. The Rev. Robert Morey said Monday that the 2020 Democratic presidential candidate attended Mass at Saint Anthony Catholic Church in Florence and was refused the sacrament because any “public figure who advocates for abortion places himself or herself outside of Church teaching.”..

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Allstate is joined by other insurers and many New York State leaders in its pursuit for comprehensive reform of the no fault system. “The no fault system is being exploited and responsible citizens are the victims,” Conte said. “Without the support of lawmakers, incidents of fraud will continue to increase.

When we first saw Robert the doll, he just looked like a worn out doll that sat in an enclosed exhibit. My husband and I stood and looked at Robert for a few minutes, we both had a bit of a laugh about the doll. We agreed that Robert the doll did not appear so menacing.

Les amateurs de vins auraient intrt largir leurs horizons vers les bires de dgustation des quatre coins du monde, sans oublier celles labores avec maestria au Qubec. Ayant t initi aux vins travers le monde de la bire, au milieu des annes 80, je n’ai jamais perdu le got de cette boisson aux saveurs plurielles. Au fil des dernires annes, j’ai remarqu une importante volution qualitative des bires du monde.

His subordinates, especially Party rather than military, would present information more in the form that they believed he wanted to hear, rather than what professional military opinion advised. For example, the Me 262 was introduced to him as a light bomber, even though, at the time, it had no bomb carrying equipment and was purely a defensive interceptor, although a very good one. [7] It could have devastated Allied bomber streams.

SNC released a short 1 minute video of the test flight see below showing the helicopter drop, dive, glide and flare to touchdown. The failure of the landing gear to drop is clearly seen. But the video cuts away just prior to touchdown and does not show the aftermath of the skid or damage to the vehicle..

We present evidence that lysosomes are intimately associated with the sarcoplasmic reticulum (SR) in ventricular myocytes; a median separation of 20 nm in 2D electron microscopy and 3.3 nm in 3D electron tomography indicates a genuine signalling microdomain between these organelles. Fourier analysis of immunolabelled lysosomes suggests a sarcomeric pattern (dominant wavelength 1.80 m). Furthermore, we show that lysosomes form close associations with mitochondria (median separation 6.2 nm in 3D studies) which may provide a basis for the recently discovered role of NAADP in reperfusion induced cell death.

Having lost his wife and business, Bruno (Elio Germano) spends lots of time at the centre with tweenage son, Nicola (Francesco Gheghi). He tries to be friendly to Numa when they meet in reception and allows him to borrow his phone when they bump into each other in the storeroom. But Bruno is outraged when Numa blows his credit on a call to Stockholm and Angela has to intervene when they start fighting.

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“[Mom] had this look on her face like, ‘What did I do wrong,'” says Shawn. “Like, ‘What did I do to these kids,'” adds Marlon. The pair has just finished recounting their strict upbringing (“Aren’t they kind of like the Osmonds?” wondered a fellow journalist before the brothers entered the room), and they’re dutifully attempting to answer reporters’ questions about pushing the shock joke envelope in these post South Park days.

President and CEO James May said, if enacted, the higher fee would push some airlines into bankruptcy. Funds from the higher fee would be used to buy explosive detection systems. May 9, 2005. It was merciful that he came out of the KC game, because he was INJURED and needed to rehab and return in the final game, like I said he would, and lead the team to a SB victory, like I said he would. And even then he was not at full strength. If he had not suffered an injury half way through the 2014 season he was on target for close to as good a year as he had in 2013 when he broke all records.

However, findings varied by baseline blister severity. For patients with mild or moderate blistering (30) net costs and outcomes were similar. For patients with severe blistering (>30) net costs were higher (2558, 95% CI “82 to 5198) and quality of life poorer ( “0.090 QALYs, 95% CI “0.222 to 0.042) for patients starting on doxycycline.

AciclovirAciclovir (pronounced a’syclo’vear) is available over the counter as a cream. It’s very expensive and is sold in small quantities, usually no greater than 2g. Aciclovir is best effective when used as soon as itching starts and will usually reduce the healing time.

Thanks, man. Being constructive, if you want to do it, it needs to become your obsession.I was the Location Manager, Health and Safety Officer and Best BoyWe used the Kevin Smith method of stealing the electricity from street lightsEDIT: Paraglider with you on that one the pre production and planning was great fun, and the filming was an adrenaline fuelled, sleepless ten days. Post production a little dull.Sufidreamerposted 10 years agoin reply to thisYou can hire all of the stuff that you need, from cameras and sound booms down to clapper boards.

The results of numerous research studies support Dr. Sahelia’s theory, including electron microscope analysis of the hippocampus region of the brain, which demonstrated ALC’s ability to reverse the age related deterioration of mitochondria. Furthermore, according to Professor Gary Null, autopsies show that people who had Alzheimer’s experienced 25 to 40 percent less ALC transferase activity than people without Alzheimer’s.

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Zero artificial sweeteners, colors or alcohol. Learn more at the Health Ranger Store and help support this news site.In a prior study, the researchers showed that it was possible to accurately detect lung cancer through genetic testing of cells taken from the lining of the bronchus (the epithelial layer). In the new study, they sought to determine whether the same test could be successfully performed on cells collected less invasively from the nasal cavity, instead.group previously derived and validated a bronchial epithelial gene expression biomarker to detect lung cancer in current and former smokers, Spira said.

Not an easy babe, he was already difficult, rather demanding, and destined to be spoiled. Gorgeous, blond, dark almond shaped eyes, perfection. In my arms, this little bundle of joy, was to become the greatest love of my life, the newest member of my family, my Scottish Terrier..

Examine the acceptability, feasibility and tolerability of the intervention and 2. Assess the feasibility of running a trial across 12 community settings (4 day centres, 4 care homes, 4 community groups). Centres were randomised to either CCBE, group reminiscence or usual care.

An HRD ministry official said it was necessary because frequent strikes by DU teachers and other staff hampered studies and the conduct of exams. The university’s teachers and students have organised protests in the last two years over a range of central government decisions, including the graded autonomy scheme of UGC, which allows some institutions more autonomy, and revised rules for the appointment and promotion of university teachers. Most recently DU teachers boycotted examination paper evaluations in May June this year..

Ethical approval for the study was obtained from the Faculty of Health, Life and Social Sciences Ethics Committee at the University of Lincoln in May 2012. Data were collected in two stages; the administration of Scales of Psychological Well Being (SPWB; 10) and individual interviews. In total, 112 respondents completed the questionnaire (31 PCR participants, 23 participants from the choir and 62 from Walkwell).

Objectives: To compare prevalence and types of dispensing errors and pharmacists TM labelling enhancements, for prescriptions transmitted electronically versus paper prescriptions.Results: Overall, we identified labelling errors in 5.4% of 16 357 dispensed items, and content errors in 1.4%; enhancements were made for 13.6%. Pharmacists also edited the label for a further 21.9% of electronically transmitted items. Electronically transmitted prescriptions had a higher prevalence of labelling errors (7.4% of 3733 items) than other prescriptions (4.8% of 12 624); OR 1.46 (95% CI 1.21 to 1.76).

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Shifting human resources for health in the context of ART provision: qualitative and quantitative findings from the Lablite baseline studyNkhata, M. J., Muzambi, M., Ford, D., Chan, A. K., Abongomera, G., Namata, H., Mambule, I., South, A., Revill, P., Grundy, C., Mabugu, T., Chiwaula, L., Hakim, J., Kityo, C., Reid, A., Katabira, E., Sodhi, S., Gilks, C.

MORE: Port RSL on the brink of insolvency The club remained shut yesterday, with representatives from Hall Chadwick on site. A spokesman for Hall Chadwick said a statement clarifying the club position would be made today, but many members did not believe the situation should have reached this stage. Port Kembla Chamber of Commerce president Ian Fulford said there was a lot of confusion over the position of the club.

At least the ST’s special steering wheel creates the illusion of sportiness with its small diameter and girthy grips at 3 and 9. It’s a little over the top, but then so were BMW’s M sport steering wheels from a few years back. Is there really a market for a vehicle like the 2020 Ford Explorer ST? It’s a three row family crossover with 400 horsepower, high performance brakes, a firm suspension and a “top speed target for track drivers of 143 mph.” Well, Ford is certainly about to find out, because there’s really nothing like it out there.

To make matters even worse than worse, Jimmy Butler left this embarrassing showing with an apparent knee injury. Source: TwitterSource:Twitterabsence of Jenner would return the home court advantage the Sixers have garnered since March of last year. A 20 game home regular season win streak has been snapped, Ben Simmons career is in jeopardy, and an innocent man in Jimmy Butler is injured.

In a first, the organisation invited Pakistan ambassador to Washington to attend the convention. For a long time, the Sindhi community in North America hasn enjoyed a strong relationship with the Pakistan Embassy. The community has preferred to keep a distance from those in power.

Is no turning back, my family needs the money more than ever. We have to reach the United States. Controls, dozens of Haitians show up in Tijuana every day, almost all of them arriving after an arduous three month trip traversing jungles and mountains from Brazil where they sought refuge following the earthquake..

The labor secretary wants to stay in the Reagan Cabinet. But Washington insiders expect that he’ll be gone early in ’83. Substantial changes appear to be coming in the Reagan administration. According to police, all of the crimes happened overnight, beginning July 24 with a 2018 BMW stolen from a garage. Two days later, Jones allegedly stole a 2017 Honda Civic, from a driveway. The next day, July 27, a Ford F 450 truck was stolen while parked in front of a home.

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The American Cancer Society recommends that everyone has a test for colon cancer at age 50. However, a quarter of people surveyed say their doctor had never discussed colon cancer screening with them, and another quarter said they didn’t get screened because they had no symptoms of the disease. Considering colon cancer is the second largest cause of cancer related death in the US, and bowel cancer is the third most common type of cancer in the UK, it would be prudent not to wait until you do have symptoms, but get yourself checked out anyway.

Cipollone, I. Ruffini, F. Fano, M. Item Type:Conference or Workshop contribution (Paper)Item Status:Live ArchiveAbstractFollowing recent developments, most brain imaging modalities (MR, CT, SPECT, PET) can nowadays be registered and integrated in a manner almost simple enough for routine use. By design though, these modalities are still not able to match the principles and near real time capabilities of the much simpler (but of lower spatial resolution) EEG, thus the need to integrate it as well, along with for some patients the more accurate invasive electrophysiology measurements taken directly in contact with brain structures. A standard control CT (or MR) is routinely performed after the implantation of invasive electrodes.

The recipe makes quite a few, so freeze the leftovers and have them for another night.1/2 teaspoon salt, dividedSpray muffin tin with cooking spray. Heat oven to 375 degrees. Combine 1/4 teaspoon salt, dash of pepper, onion, mushrooms, and carrots with olive oil in small bowl.

Teach me what it like to grow up in poverty. I hear, mom didn have any money or dad is incarcerated. Maybe that can give understanding on why people don like the police.”. We are really impressed with the Huawei MateBook X Pro. Yes, it’s an Apple MacBook Pro clone (it even comes in Space Gray), but the laptop is one of the best Windows 10 machines for business and personal use. In fact, it runs Windows 10’s Signature Edition, which means there’s no free trial software or bloatware that you will never use and will only bog down the laptop.

A transport protein called GLUT1 is shut down by genistein. This protein sends glucose into the cells where it is used to generate energy. Slowing the transport of glucose means less energy production not only of thyroid hormone, but of every other action in the body..

In the presence of a lipid membrane MD simulations suggested that under hydrophobic mismatch the peptide is seen to insert via oblique orientation with a phenylalanine residue (PHE3) playing a key role in the membrane interaction. There is evidence of snorkelling leucine residues leading to further membrane disruption and supporting the high level of lysis observed using calcein release assays (76%). Simulations performed at higher peptide/lipid ratio show peptide cooperativity is key to increased efficiency leading to pore formation..

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Raffles and prizes will be available. With dinner at 7. Cost is $5 for 25 targets for members. The Patron was so minded to forward the matter to the Federal Government which in turn requested the Chief Justice of the Lahore High Court to nominate one judge for a one man judicial Commission under the Commission of Inquiry Act, 1956. On the recommendation of the Learned Chief Justice, Mr. Justice Malik Muhammad Qayyum was appointed to this Commission..

The case also highlights a difference between the Trump administration and that of the previous administration. During the Obama administration, the Equal Employment Opportunity Commission, an independent agency responsible for enforcing federal law that makes it illegal to discriminate based on sex, took the position that federal law does encompass protections for gender identity and sexual orientation. That is the position of the agency today, as posted on its website..

However, studies have shown that these practices are fading in the UK, because of fragmentation, adversarialism and, clients preference for lowest tender, whilst cost consultants struggles to be involved in collaborative working especially, during costing activities. The primary research used a multiple case study approach, which aggregated data from interviews and documentary analysis (financial business case; costing estimating manuals etc.). Overall, 23 interviews were captured with cost consultants, lean practitioners, main contractors among others within the building and infrastructure sectors in the UK.

The Trump Administration has carried forward the Obama Administration’s policy of opposing the negotiations. An alarming related development is that Christopher Ford, a former US Special Representative for Nonproliferation now serving on the National Security Council, has stated that the administration is reviewing “whether or not the goal of a world without nuclear weapons is in fact a realistic objective, especially in the near to medium term.” Ford, a lawyer, knows very well that the United States is legally bound by Article VI of the NPT to pursue in good faith negotiations on effective measures relating to nuclear disarmament. Allies is that a nuclear ban treaty will undermine the NPT.

Sixteen Palestinian men, some with ties to convicted terrorists, were indicted Thursday in the alleged scheme that spans New York, Maryland, Delaware, Virginia and New Jersey states.Although it is unclear where the illicit proceeds ended up, similar schemes have funded organizations such as Hamas and Hezbollah, according to Ray Kelly, commissioner of the New York Police Department.case started because we were being vigilant about terrorism, Kelly said in a statement. Discovered that individuals who were on our radar for links to known terrorists were engaged in a massive raid on the New York Treasury in the form of cigarette tax avoidance. Of the suspects had financial ties to Omar Abdel Rahman, the blind cleric serving a life sentence for a conspiracy to blow up New York City landmarks.New York Attorney General Eric T.With his brother, Samir Ramadan, 40, they allegedly obtained cigarettes from a wholesaler in Virginia and smuggled the untaxed cartons to a storage facility in Delaware.The lucrative business of cigarette smugglingAdel Abuzahrieh, 42, of Brooklyn, would allegedly drive from New York to the storage facility several times a week with tens of thousands of dollars in cash to be exchanged for untaxed cartons of cigarettes.

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Baumann says. That especially true at night, when skin shifts into repair mode. The one antioxidant to avoid at night is vitamin C; see “Vitamin C can be finicky.”Free radicals can damage sebum (your skin natural oils), which then promotes inflammation around follicles and can lead to breakouts, Dr.

C. M., Dijkstra, T. Rueschemeyer, S. During consorts, significant decrements in mother infant ventroventral contact and proximity, and in the roles played by mothers in maintaining contact and proximity were observed, while maternal rejection increased significantly. Social behaviour of infants and allomaternal care they received were unaffected by the mother’s consort activity. Effects of consorts were more evident in female than in male infants, but were not influenced by the infant age or by the quality of the relationship it had with its mother before the mating season.

The findings highlight the significant role clinical directors can play in closing the gap between these two groups. They also suggest that the multiple demands of trusts are better served by adopting a more flexible budget than by abandoning the budget altogether.In terms of MA’s strategic contribution, the findings indicate that the Trust engages in strategy formulation but pays little attention to strategy execution; a range of factors, such as efficiency targets, the contract between the Trust and the commissioners, and rising demand, force managers to focus their attention on short term performance at the expense of strategy execution. However, while MA appears to make little or no contribution to encouraging strategic behaviour (there being no link between the Trust’s operations and its strategy), the findings do show that management accountants (MAs) contribute significantly to the strategic decision making process.

In an emotional defense of Bailey last week, Bondi said of his departure, do not know who made that call at all. But I do not think Rick Scott would do that. Bondi suggested that the matter may have been orchestrated by Scott chief of staff, Melissa Sellers, and his then general counsel, Pete Antonacci..

We gave up none of those. We let the one get out. Pretty darn good job there. The research contributes to the study of institutional work by incorporating sociomateriality (Orlikowski Scott, 2008) into the analysis of embedded agency. The study has implications for those seeking to govern by metrics, as it shows how striking a balance between what can be measured and what ought to be measured is complicated and requires a lot of work. Lastly, the research opens up a number of venues for future research into CSR, SRI and institutional work..